The larger-displacement V6 option on this same C-Class generation — more power than the C300, but built on the identical M272 family with the identical balance shaft gear concern.
Genuinely stronger performance than the C300 on the same chassis, but mechanically it's the same M272 family — the balance shaft gear concern detailed on the dedicated engine page applies without exception.
If you're cross-shopping against the C300, the engine-specific risk is identical; the decision comes down to performance preference and price, not reliability.
This is about the car itself — for engine-specific failure points, see the dedicated engine page below.
This C350 shares its M272 V6, and that engine's balance shaft concern, with the related C300. The full checklist lives on the shared engine page.
FULL ENGINE BREAKDOWNMercedes-Benz M272/M273 V6/V8 — Reliable or Not →Ask whether the balance shaft gear has been proactively replaced, and get documentation if so.
Listen for a rattling noise on cold start that may lessen as the engine warms.
Find a Mercedes specialist rather than a generalist mechanic for any pre-purchase inspection.